New data confirm combination nivolumab and ipilimumab as the best treatment for unresectable malignant pleural mesothelioma (MPM).

The data come from the CheckMate 743 study ( Identifier: NCT02899299), which showed superior 3-year overall survival (OS) with nivo-ipi over standard chemotherapy and no new safety signals associated with nivo-ipi.

Advanced MPM has an extremely poor prognosis. Standard-of-care pemetrexed plus cisplatin chemotherapy produced a response rate of 41% and a median OS of 12.1 months in a phase 3 trial, but most patients experience no enduring benefit from treatment.

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