The muscular dystrophies are known to target various muscle groups differentially. In addition to making limb muscles weak, muscular dystrophy (MD) can also lead to decreased function of specific muscles involved in respiration causing breathing difficulties as well as leading to cardiac problems.
Using mouse models, researchers found that abdominal muscles may be severely involved in the muscular dystrophy process. The abdominal muscles are important to provide respiratory support when the diaphragm muscle has been damaged by the disease, so that additional abdominal muscle involvement can worsen the respiratory situation considerably.
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