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NIH to Evaluate Second COVID Booster in Adults

A Phase 2 clinical trial to evaluate second COVID booster shots has begun enrolling adult participants in the United States. The COVID-19 Variant Immunologic Landscape (COVAIL) trial, sponsored by the NIAID, aims to understand if different vaccine regimens—prototype and variant vaccines alone and in combinations—can broaden immune responses in adults who already have received a primary vaccination series and a first booster shot.

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