The American College of Chest Physicians (Chest) has released new clinical guidelines for venous thromboembolism (VTE) management, that provides 29 recommendations on 17 Patients, Interventions, Comparators, Outcomes (PICO) questions, four of which have not been addressed previously. “Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel” is the second update to the ninth edition of these guidelines. The last full edition of the guideline was published in 2012 and was last updated in 2016. Within the updated recommendations, the panel generated 29 guidance statements, 13 of which are graded as strong recommendations. These include: In patients with acute isolated distal deep vein thrombosis (DVT) of the leg who are managed with anticoagulation, we recommend using the same anticoagulant regimen as for patients with acute proximal DVT.In patients with cerebral venous sinus thrombosis, we recommend anticoagulation therapy for at least the treatment phase (first 3 months) over no anticoagulant therapy.In patients with acute DVT of the leg, we recommend against the use of an inferior vena cava (IVC) filter in addition to anticoagulants.In patients with thrombosis and antiphospholipid syndrome being treated with anticoagulant therapy, we suggest adjusted-dose vitamin K antagonists over direct oral anticoagulant therapy. “These guidelines help to clarify for providers the intricacies of managing patients with VTE,” says member of the expert panel, Scott C. Woller, MD, FCCP. “Serving as a comprehensive reference for any stage, the recommendations cover aspects from initial management through secondary prevention and risk reduction of post-thrombotic syndrome.” The guidance statements are intended primarily for clinicians who manage patients with VTE but may inform researchers in selecting questions for future studies. Patients and policy makers may also be informed by the guideline content.