Preliminary results from the largest US survey of tobacco consumption show a high number of people use multiple products, adding key data to the debate on the role of e-cigarettes in reducing harm from tobacco.

The results of the study, released Thursday, showed 40 percent of tobacco consumers use multiple products, such as cigarillos, hookah and cigars. Half of all combinations involved e-cigarettes.

The Population Assessment of Tobacco and Health (PATH) Study of 46,000 people, begun in 2011, is designed to answer questions about the tobacco use and behavior and help shape industry regulation.