In people with deep vein thrombosis (DVT), the rates of major bleeding and recurrent blood clots for Xarelto (rivaroxaban) in routine clinical practice were generally consistent with those observed in Phase 3 research, according to Janssen Pharmaceuticals and Bayer HealthCare.
The companies’ real-world study XALIA — which was presented at the 2015 American Society of Hematology Annual Meeting and simultaneously published in Lancet Hematology — also revealed that patients taking Xarelto had shorter length of hospital stays than those given standard anticoagulation.
Key XALIA findings included:
- Major bleeding occurred in 0.8% of patients receiving Xarelto and 2.1% of those receiving standard anticoagulation.
- There were no fatal bleeding events in the Xarelto group; two fatal bleeding events occurred in the standard anticoagulation group.
- Recurrent blood clots occurred in 1.4% of patients receiving Xarelto and 2.3% of those receiving standard anticoagulation.
- All-cause mortality occurred in 0.4% of patients taking Xarelto and 3.4% of those taking standard anticoagulation.
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