Preterm infants with respiratory distress appeared to do better with CPAP than nasal high-flow therapy in a randomized trial, according to a New England Journal of Medicine study reported by Medpage Today.

The difference in treatment failure was over 10 percentage points, and deemed so significant that it exceeded pre-specified limits and enrollment in the trial was stopped, researchers reported.

However, there were no significant between-group differences in other clinical outcomes, such as rates of intubation, bronchodysplasia, or rates of adverse events.