Influenza A may trigger an inflammatory “cytokine storm,” an excessive immune response that can lead to hospitalization or even death by increasing glucose metabolism, according to a study published in ScienceAdvances.
As the novel coronavirus pandemic grips the globe, researchers, begun investigating how glucose metabolism may affect patients with COVID-19. “We believe that glucose metabolism contributes to various COVID-19 outcomes since both influenza and COVID-19 can induce a cytokine storm, and since COVID-19 patients with diabetes have shown higher mortality,” says Shi Liu, a researcher on the study.
In general, the mechanisms that promote cytokine storms, causing some individuals to suffer more from influenza A (and, perhaps more from COVID-19) than others remain mysterious. Although glucose metabolism and inflammatory cytokine signal networks are known to have evolved together, it has not been clear whether they interact during flu infection, according to the researchers.
To learn whether glucose metabolism is related to the off-the-wall immune response brought on by influenza A, the researchers examined blood glucose levels and cytokine production in mice with the flu, finding that those treated with glucosamine produced significantly higher levels of inflammatory cytokines and chemokines than mice that did not receive glucosamine.
Additionally, the researchers analyzed glucose levels in blood samples from patients diagnosed with influenza A and healthy patients, which were collected from volunteers during physical examinations at two Wuhan University hospitals between 2017 and 2019. They determined that the hexosamine biosynthesis pathway, which metabolizes a small portion of glucose, plays an essential role in cytokine storms triggered by the flu virus.