A combination flu vaccine protected against six strains of the virus, suggesting the compound could potentially be an effective basis or component for a universal vaccine.
The double-layered nanoparticle vaccine contains the influenza virus proteins matrix protein 2 ectodomain (M2e) and neuraminidase (NA). Researchers immunized mice with the nanoparticle vaccine before exposure to influenza virus. The vaccine protected the mice against six different strains of the virus.
In the study, researchers exposed mice to one of six influenza virus strains after receiving the nanoparticle vaccine by intramuscular injection. The vaccine proved to have long-lasting immune protection, which remained unchanged against viral challenges up to four months after immunizations.