Gene profiles of bronchoalveolar lavage (BAL) cells are linked with phenotypic manifestations of sarcoidosis, according to results published in the European Respiratory Journal.
Study results also suggest 4 possible sarcoidosis endotypes with specific molecular, clinical, and environmental traits.
A team of investigators for the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study conducted a supervised and unsupervised analysis to highlight BAL cell gene signatures that may be linked to phenotypic sarcoidosis.
A total of 215 patients with pulmonary sarcoidosis were enrolled in the study and ribonucleic acid (RNA) sequencing was performed on BAL cells obtained from the cohort; 209 BAL samples were included from 8 predefined clinical groups.
