Symptoms of Scedosporium apiospermum colonization in patients with cystic fibrosis may resemble symptoms of plastic bronchitis, according to research.
Researchers described the case report of a patient with cystic fibrosis since birth who had normal lung function with an intermittent Pseudomonas aeruginosa infection treated with ciprofloxacin and tobramycin, according to the abstract. At 11 years, the patient showed normal respiratory lung function, which declined the following month.
After prescribing ceftazidime, tobramycin, steroid therapy with methylprednisone and supportive oxygen therapy, there was no clinical improvement after 48 hours. The researchers started intravenous voriconazole after a sputum culture showed growth of PA and fungal hyphae of S. apiospermum.
During a bronchoscopy, the researchers discovered thick bronchial casts obstructing the bronchial lumen and aspirated them with repeated dornase alpha.
