Ibuprofen does a good job of fighting bacteria in cystic fibrosis patients’ lungs, including two key threats, Pseudomonas aeruginosa and Burkholderia, a study shows.
Researchers said the findings support ibuprofen’s use as an add-on therapy against bacterial infections in CF. The study, “Antimicrobial Activity of Ibuprofen against Cystic Fibrosis-Associated Gram-Negative Pathogens,” was published in the journal Antimicrobial Agents and Chemotherapy.
Clinical trials have shown that adults with CF who receive a high dose of ibuprofen (50 to 100 ?g/mL plasma concentration) have less lung function decline and good to excellent pulmonary function. In children with CF aged 6 to 18 years, high-dose ibuprofen decreased the annual rate of decline in a lung function measurement, compared with placebo-treated children. The measurement was forced vital capacity.