According to CysticFibrosisNewsToday.com, SNSP113 may improve the effectiveness of antibiotics against Burkholderia cepacia infections, which are common in cystic fibrosis patients.
SNSP113 is a polycationic glycopolymers, or PAAG. It works by breaking up proteins present on the surface of bacteria, increasing their susceptibility to antibiotics.The study showed that inhaled SNSP113 can penetrate bacterial membranes, facilitating the action of antibiotics such as meropenem and tobramycin.
Lung infections caused by Burkholderia cepacia are difficult to treat in CF patients because the bacteria rapidly develop resistance to antibiotics. The result is progressive loss of patients’ lung function.