New research found that CF drugs could treat celiac disease, which is roughly three times higher among people with cystic fibrosis.
Celiac disease is an autoimmune disorder that affects 1 in 141 people in the United States. The condition is triggered by the consumption of gluten — a protein that can be found in wheat, barley, and rye and in foods such as bread, pasta, and baked goods.
The researchers studied human cell lines from people intolerant to gluten and found that a peptide called P31-43 binds to CFTR, inhibiting its function. This resulted in cellular stress and inflammation.
The findings indicate that CFTR is crucial in gluten sensitivity.