Female patients with COPD using inhaled corticosteroids have a dose-response protective effect for osteoporosis, according to a study published in the International Journal of Chronic Obstructive Pulmonary Disease.

The study evaluated 10,723 patients with COPD, including ICS users (n=812) and nonusers (n=9,911).

According to results, the incidence rate of osteoporosis per 100,000 person years was 4,395 in nonusers and 2,709 in ICS users. The higher ICS dose is associated with lower risk of osteoporosis.

The cumulative osteoporosis probability significantly decreased among the ICS users when compared with the nonusers.

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