A team of scientists has discovered a distinct mutational signature and nine significantly mutated genes associated with nasopharyngeal cancer, paving the way to developing novel therapies for this deadly disease.
The research group from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore, National University Cancer Institute Singapore (NCIS) and National University Hospital Singapore (NUH) has conducted the first successful comprehensive genomic study of nasopharyngeal carcinoma, which has a particularly high prevalence in Southern China and Southeast Asia, including Singapore. The findings provide an enhanced road map for the study of the molecular basis of this form of cancer.
Nasopharyngeal carcinoma arises from the epithelial lining of the nasopharynx, the upper part of the throat behind the nose. Unlike cancers that have been extensively studied, such as breast and colon cancers, there is currently limited understanding of the molecular biology of nasopharyngeal cancer. To date, no targeted therapy has been established and there is an urgent need for a comprehensive genomic landscape of this disease to guide the development of novel therapies.
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