Vitamin D may be protective among asthmatic obese children living in urban environments with high indoor air pollution, according to a new study published in The Journal of Allergy and Clinical Immunology: In Practice.
The study was out of Johns Hopkins University School of Medicine and funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health.
“The research team has identified many factors that make children susceptible to health problems from air pollution throughout Baltimore’s inner city,” said Kimberly Gray, PhD, administrator for the Children’s Environmental Health Research Centers program at NIEHS.
According to the Centers for Disease Control and Prevention(link is external), one in 12 children in the U.S. have asthma, which totals 6.1 million children nationally. Additionally, asthma disproportionately impacts urban minority populations, such as black children. Higher indoor air pollution, from sources such as cigarette smoke, cooking, burning of candles, and incense, is linked to greater respiratory problems, including worsening of asthma symptoms and more hospital visits.
“Asthma is an immune-mediated disease,” said Sonali Bose, MD, lead author of the study and assistant professor of medicine, pulmonary, critical care, and sleep medicine at the Icahn School of Medicine at Mount Sinai, and adjunct faculty at Johns Hopkins. “From previous scientific studies, we knew that vitamin D was a molecule that may influence asthma by impacting antioxidant or immune-related pathways.”
Bose explained that at the time the study was being conceived, researchers were seeing vitamin D deficiencies across the U.S. “It became very clear that African-Americans were at higher risk for vitamin D deficiency, particularly black children,” she said. “We were also noticing a heavy burden of asthma in inner city minority children. It seemed as though vitamin D deficiency and asthma were coincident and interacting in some way.”
The study tested three factors – air pollution levels in homes, blood vitamin D levels, and asthma symptoms – in 120 school-aged children with preexisting asthma in the Baltimore area. One-third of the study participants were also obese. The children were evaluated at the start of the study and three times over the next nine months.
Overall, they found that having low blood vitamin D levels was related to the harmful respiratory effects of indoor air pollution among obese children with asthma. Conversely, in homes that had the highest indoor air pollution, higher blood vitamin D levels were linked to fewer asthma symptoms in obese children.
“What surprised us the most was that the findings of the study showed the effects were most pronounced among obese children,” Bose said. “This highlights a third factor at play here – the obesity epidemic – and helps bring that risk to light when considering individual susceptibility to asthma.”