According to a review published in Allergy, the prevalence of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (NERD) is approximately 9% among individuals with asthma. Also, asthma morbidity is increased among those with NERD. Daniel R. Morales, MBChB, and colleagues conducted a systematic review to examine the prevalence of NERD among patients with asthma and its link with asthma morbidity.
Studies were identified that diagnosed NERD using blinded, placebo-controlled oral provocation challenge tests (OPCTs) or by self-reported history.
According to a Medical Xpress news report, the researchers found that in adults with asthma the prevalence of NERD was 9.0% and 9.9% using OPCTs and self-reported history from questionnaires, respectively. In adults with NERD, the mean provocative dose of oral aspirin was 85.8 mg. In addition, compared to people with aspirin-tolerant asthma, people with NERD had increased risks of uncontrolled asthma, sever asthma and asthma attacks, emergency room visits, and asthma hospitalization.
The authors of the study write, “Respiratory reactions triggered by oral aspirin in people with asthma are relatively common. On average, respiratory reactions were triggered by clinically relevant doses of oral aspirin. Asthma morbidity was significantly increased in people with NERD, who potentially require more intensive monitoring and follow-up.”
Source: Medical Xpress