Chemical in Many Air Fresheners Might Reduce Lung Function’, ‘New research shows that a chemical compound found in many air fresheners, toilet bowl cleaners, mothballs and other deodorizing products, may be harmful to the lungs. Human population studies at the National Institute of Environmental Health Sciences (NIEHS), a part of the National Institutes of Health, found that exposure to a volatile organic compound (VOC), called 1,4 dichlorobenzene (1,4 DCB) may cause modest reductions in lung function. ‘, ‘July 27, 2006 — New research shows that a chemical compound found in many air fresheners, toilet bowl cleaners, mothballs and other deodorizing products, might be harmful to the lungs. Human population studies at the National Institute of Environmental Health Sciences (NIEHS), a part of the National Institutes of Health, found that exposure to a volatile organic compound (VOC), called 1,4 dichlorobenzene (1,4 DCB) may cause modest reductions in lung function.
“Even a small reduction in lung function may indicate some harm to the lungs,” said NIEHS researcher Stephanie London, MD, lead investigator on the study. “The best way to protect yourself, especially children who may have asthma or other respiratory illnesses, is to reduce the use of products and materials that contain these compounds.”
The researchers examined the relationship between blood concentrations of 11 common VOCs and lung function measures in a representative sample of 953 adults. VOCs are a diverse set of compounds emitted as gases from thousands of commonly used products, including tobacco smoke, pesticides, paints, and cleaning products. VOCs are also released through automotive exhaust. The researchers found that of the common VOCs analyzed, which included benzene, styrene, toluene, and acetone, only the compound 1,4 DCB was associated with reduced pulmonary function, and this effect was seen even after careful adjustment for smoking, The researchers found that 96% of the population samples had detectable 1,4 DCB blood concentration levels. African Americans had the highest exposure levels and non-Hispanic whites the lowest.
This particular VOC, 1,4 DCB, is a white solid compound with a distinctive aroma, similar to mothballs. It is typically used as a space deodorant in products such as room deodorizers, urinal and toilet bowl blocks, and as an insecticide fumigant for moth control.
“Because people spend so much time indoors where these products are used, it’s important that we understand the effects that even low levels might have on the respiratory system,” said Leslie Elliott, PhD, a researcher on the NIEHS-funded study. “There has been very little research on the health effects of this particular compound in non-occupational settings.”
Data from 953 adults 20-59 years old who had both VOC blood measures and pulmonary function measures are included in the study published in the August issue of Environmental Health Perspectives. Four pulmonary function measures were used in the analyses. The researchers found modest reductions in pulmonary function with increasing blood concentrations of 1,4 DCB.
There was approximately a 4% decrease in the test which measures forced expiratory volume in 1 second (FEV1) between the highest and lowest levels of exposure.
The researchers assessed the influence of other factors in an individual’s environment that could be related to pulmonary function and to 1,4-DCB exposure, such as type of heating, use of wood fires, age of house, presence of furred pets, occupation, socioeconomic status, environmental tobacco smoke, smoking history, and diagnosis of asthma or emphysema. The authors noted that participants might have been exposed to other agents not assessed in this study1that have been linked to both respiratory impairment and levels of 1,4-DCB.
“This research suggests that 1,4-DCB may exacerbate respiratory diseases,” said David A. Schwartz, MD, NIEHS director. “As part of the new disease-focused approach at NIEHS, researchers will use this information to better understand the pathogenesis of respiratory diseases.”