According to new research in the American Journal of Respiratory and Critical Care Medicine, a study of over 300 severe asthmatics found their sputum samples were more than twice as likely to have more inflammatory cells (eosinophils) in morning clinics than in the afternoon.

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Doctor and patients have long known that asthma symptoms are at their worst in the small hours of the morning. But previous research has shown that the worsening symptoms are biological in cause, rather than a result of lying down.

“These research results are really exciting but at an early stage – our aim was to understand a bit more about how the body clock affects the biochemistry of a person with asthma.”