Researchers at UT Southwestern Medical Center, Dallas, have found that a tiny molecule that spurs the progression of non-small cell lung cancer (NSCLC) may play a role in fighting the disease. The study, published in the journal Cancer Cell, looked at how the molecule behaves in mice.
Scientists have known that the molecule microRNA-21, or miR-21, is present in overabundant quantities in human tumors, including NSCLC. Until now, however, it was unclear whether miR-21 contributed to the development of lung cancer, or whether it was simply an indicator of the presence of the disease.
The researchers in this study used mice that had been altered specifically to harbor NSCLC. In some of these mice, they genetically engineered the animals to produce too much miR-21. In another group, they deleted the miR-21 gene altogether, which eliminated the molecule in the rodents.
In animals with cancer, the results showed that too much miR-21, or overexpression, promotes the formation, growth, and survival of new tumors by turning off certain genes that normally allow cancer cells to die. In fact, at 18 weeks of age, the study group with overexpressed miR-21 had significantly more tumors than their lung-cancer-carrying littermates with normal levels of miR-21. Healthy rodents engineered to overexpress miR-21 did not develop cancer.
"These results indicate that overexpression of miR-21 alone is not enough to initiate tumors in a healthy animal. Instead, it appears that miR-21 enhances the growth and survival of existing lung cancer," said Mark Hatley, MD, a pediatric scientist development program fellow sponsored by the National Institutes of Health’s Eunice Kennedy Shriver National Institute of Child Health and Human Development.
According to Eric Olson, PhD, chairman of molecular biology at UT Southwestern and the study’s senior author, the experiments also show that deleting miR-21 sensitizes the animals’ cancer cells to a certain kind of chemotherapy, suggesting that inhibiting miR-21 in lung-cancer patients could be of therapeutic value.
"Methods currently exist to pharmacologically manipulate molecules like miR-21," said Olson. "More research will be needed before we know whether this is applicable to humans, but it’s possible that a drug designed to inhibit miR-21 could help keep cancer at bay."
Source: UT Southwestern Medical Center